A halin yanzu, akwai nau'o'in shirye-shiryen paclitaxel iri uku a kasuwa a kasar Sin, ciki har da allurar paclitaxel, Liposomal paclitaxel da Albumin-bound paclitaxel. Dukansu alluran paclitaxel da Liposomal paclitaxel don allura suna buƙatar maganin rashin lafiyar pretreatment, amma me yasa Albumin- daure paclitaxel baya buƙatar magani?Bari mu kalli waɗannan abubuwan.
Me yasa paclitaxel da ke ɗaure Albumin baya buƙatar pretreated? Yanzu bari mu fahimci tsarin rashin lafiyar na shirye-shiryen paclitaxel guda uku.
1.Paclitaxel allura
Don ƙara ruwa solubility na paclitaxel, da sauran ƙarfi ga paclitaxel allura ya hada da polyoxyethylene Castor man da ethanol.Polyoxyethylene Castor man, a matsayin allergen, yana da wasu wadanda ba ionic block copolymers a cikin kwayoyin tsarin, wanda zai iya motsa jiki ya saki histamine. Kuma yana haifar da rashin lafiyan halayen. Kafin amfani da asibiti, dole ne a yi amfani da glucocorticoids da antihistamines don pretreatment.
2.Liposomal paclitaxel
Liposomal paclitaxel sune galibi phospholipid bimolecular liposomes tare da diamita na 400 nm da aka samar da lecithin da cholesterol a wani kaso.
Duk da haka, wasu nazarin sun nuna cewa paclitaxel kanta na iya haifar da hypersensitivity, wanda ke da alaka da kunna tsarin rigakafi da basophils, IgE da IgG ke yi. Amma idan aka kwatanta da allurar paclitaxel, rashin lafiyarsa ya ragu. buƙatar maganin rashin lafiyan kafin amfani.
3.Albumin-daure paclitaxel
Albumin-daure paclitaxel, tare da albumin ɗan adam a matsayin mai ɗaukar hoto, yana da fa'idodin sauƙi na ruɓewa a cikin vivo, ƙarin tarin magunguna a cikin ciwace-ciwacen ƙwayoyi, niyya mai ƙarfi da ingantaccen ingantaccen chemotherapy.
A cikin karatun Phase I, II ko III akan albumin-bound paclitaxel, ko da yake ba a yi pretreatment ba, ba a sami wani mummunan ra'ayi ba.Dalili na iya zama cewa babu polyoxyethylene castor man kuma abun ciki na free taxol a cikin jini ya ragu. Don haka, ba a ba da shawarar yin magani kafin gudanar da albumin bound paclitaxel ba a halin yanzu.
Lura: Yiwuwar inganci da aikace-aikacen da aka gabatar a cikin wannan labarin duk sun fito ne daga wallafe-wallafen da aka buga.
Yunnan Hande Biotechnology Co., Ltd ya ƙware a cikin samar dapaclitaxel APIfiye da shekaru 20, kuma yana ɗaya daga cikin masana'antun masu zaman kansu na duniya na paclitaxel API, maganin ciwon daji da aka samo asali, wanda Amurka FDA ta amince da shi, EDQM na Turai, TGA Ostiraliya, CFDA na kasar Sin, Indiya, Japan da sauran hukumomin kula da ƙasa. .Hande zai iya samar da ba kawai high quality-paclitaxel albarkatun kasa,amma kuma ayyukan haɓaka fasaha masu alaƙa da ƙirar paclitaxel.Don ƙarin bayani, da fatan za a ji daɗin tuntuɓar mu a 18187887160.
Lokacin aikawa: Dec-21-2022