Paclitaxel ne mai kyau na halitta anti-ciwon daji magani da aka samu a halin yanzu.An yi amfani da ko'ina a asibiti jiyya na ovarian cancer, nono, ciwon huhu, kai da kuma wuyansa ciwace-ciwacen daji, esophageal ciwon daji, ciki ciwon daji da taushi nama sarcoma.Paclitaxelya jawo hankalin masana kimiyya sosai saboda hadaddun tsarin sinadarai na zamani, na musamman hanyoyin nazarin halittu na aiki, amintaccen aikin rigakafin cutar daji, da karancin albarkatu. A cewar kididdigar, sama da manyan dakunan gwaje-gwaje 30 a duniya sun tsunduma cikin binciken Total. kira na paclitaxel, kuma gasar tana da zafi sosai, wanda ya zama abin da ake mayar da hankali ga ilimin sunadarai na kwayoyin halitta a ƙarshen karni na 20.
Na musamman anti-tumor inji na paclitaxel
Paclitaxel na iya yin Tubulin da Tubulin dimer waɗanda ke yin microtubules rasa Ma'aunin Dynamic, haifar da haɓaka Tubulin polymerization, taron microtubule, da hana depolymerization, don daidaita microtubules da hana Mitosis na ƙwayoyin kansa da haifar da apoptosis, don haka yana hana haɓakar cutar kansa yadda ya kamata. Kwayoyin da kuma taka rawar anti-cancer.
A gaskiya ma, Tubulin, wanda ke da alaka da cell Mitosis, ya kasance kusan a duk duniya a cikin dukkanin kwayoyin eukaryotic. Za su iya yin polymerize cikin microtubules a sake juyewa. Rabuwar chromosome yana buƙatar taimakon waɗannan microtubules. tarwatsewar guduma kamar microtubules na iya fifita kashe sel tare da rarrabuwa mara kyau.Wasu mahimman magungunan rigakafin cutar kansa, irin su colchicine, Vinblastine, Vincristine, suna taka rawar anti-tumor ta hana Tubulin daga sake yin polymerization.
Sabanin magungunan mitosis da magungunan ƙari.paclitaxelshine magani na farko da aka samo wanda zai iya hulɗa tare da Tubulin polymer, wato, yana aiki ta hanyar haɗawa tare da microtubules don tabbatar da su kwanciyar hankali. ganowa ya jawo ƙarin masana ilimin halitta don amfani da supaclitaxela matsayin kayan aikin bincike a cikin biomedicine, binciko wuraren da ba a sani ba na ayyukan tantanin halitta da kuma gano sabbin hanyoyin magungunan anticancer.
Bayani: Yiwuwar inganci da aikace-aikacen da aka ambata a cikin wannan labarin duk sun fito ne daga wallafe-wallafen jama'a.
Yunnan Hande Bio-tech yana mai da hankali kan samar da paclitaxel tsawon shekaru 28.Kamfanin samarwa ne mai zaman kanta na kayan albarkatun paclitaxel, wanda hukumomin kula da ƙasa kamar FDA a Amurka, EDQM a Turai, TGA a Ostiraliya, CFDA a China, Indiya, da Japan suka amince da su.Yunnan Handepaclitaxelyana samuwa a hannun jari kuma masana'antun ke sayar da su kai tsaye.Barka da zuwa tambaya.
Lokacin aikawa: Juni-12-2023