An yi la'akari da magungunan Paclitaxel a matsayin magani na farko don ciwon nono, kuma ana amfani da su sosai a asibiti don ciwon daji na ovarian, ciwon huhu, ciwon kai da wuyansa, ciwon daji na esophageal, ciwon daji na ciki da sarcoma mai laushi.A cikin 'yan shekarun nan, ta hanyar ci gaba da binciken magungunan paclitaxel da ci gaba da inganta tsarin tsari, waɗannan magungunan yanzu sun hada da allurar paclitaxel, docetaxel (docetaxel), lipsomal paclitaxel da albumin-bound paclitaxel.Don haka menene bambance-bambance tsakanin waɗannan magungunan paclitaxel, bari mu ƙarin koyo game da su a ƙasa.
I. Bambance-bambance a cikin ayyuka na asali
1. Paclitaxel allura: An nuna shi don layi na farko da kuma bibiyar maganin ciwon daji na ovarian na ci gaba, maganin ciwon daji na nono na lymph node-positive ciwon nono bayan ka'idar tsari na adriamycin-dauke da chemotherapy, ciwon nono a cikin ciwon nono metastatic cewa ya gaza haɗin chemotherapy ko sake dawowa a cikin watanni 6 na adjuvant chemotherapy, maganin layin farko na ciwon huhu mara ƙanƙanta, da kuma jiyya na layi na biyu na carcinosarcoma mai alaƙa da cutar AIDS.
2. Docetaxel: Don maganin ci gaba ko ciwon daji na nono wanda ya gaza kafin chemotherapy;don maganin ci-gaban ko ciwon daji na huhu mara ƙarami wanda ya kasa tare da cisplatin na tushen chemotherapy.Hakanan yana da tasiri ga ciwon daji na ciki da ciwon prostate.
3. Liposomal paclitaxel: Ana iya amfani da shi azaman chemotherapy na farko don ciwon daji na ovarian da chemotherapy na farko don maganin ciwon daji na ovarian metastatic cancer, kuma ana iya amfani dashi a hade tare da cisplatin.Hakanan za'a iya amfani da shi don bin diddigin masu cutar kansar nono waɗanda aka yi musu maganin chemotherapy na yau da kullun da ke ɗauke da adriamycin ko don kula da marasa lafiya da suka sake dawowa.Hakanan za'a iya amfani dashi a hade tare da cisplatin azaman chemotherapy na farko ga marasa lafiya da ciwon huhu marasa ƙananan ƙwayoyin cuta waɗanda ba za a iya bi da su tare da tiyata ko radiotherapy ba.
4. Albumin-bound paclitaxel: wanda aka nuna don maganin ciwon daji na nono wanda ya kasa hadewar chemotherapy ko kuma ciwon nono wanda ya sake dawowa cikin watanni 6 bayan adjuvant chemotherapy.Sai dai idan akwai rashin daidaituwa na asibiti, chemotherapy na baya yakamata ya haɗa da wakili na anticancer anthracycline.
II.Bambance-bambance a cikin aminci na miyagun ƙwayoyi
1. Paclitaxel: rashin ruwa mara kyau.Gabaɗaya, allurar za ta ƙara man kastor mai maye gurbin polyoxyethylene da ethanol don inganta narkewar paclitaxel a cikin ruwa, amma ana fitar da histamine lokacin da aka lalata man castor mai maye gurbin polyoxyethylene a cikin vivo, wanda zai iya haifar da mummunan rashin lafiyan kuma yana iya ƙara tsanantawa. na gefe neurotoxicity na paclitaxel, kuma yana iya rinjayar yaduwar kwayoyin miyagun ƙwayoyi zuwa kyallen takarda kuma yana tasiri tasirin anti-tumor.
2. Docetaxel: ruwa mai narkewa yana da ƙasa, kuma yana buƙatar zama mai narkewa ta hanyar ƙara polysorbate 80 da ethanol anhydrous, duka biyun na iya ƙara yawan abin da ya faru na mummunan halayen kuma zai iya haifar da rashin lafiyan halayen da halayen hemolytic.
3. Liposomal paclitaxel: maganin yana kunshe a cikin nau'in lipid-kamar bilayers don samar da ƙananan vesicles, kuma ana sanya maganin a cikin ƙwayoyin liposomal ba tare da polyoxyethylene maye gurbin man castor ba da ethanol anhydrous, wanda ke haifar da rashin lafiyan halayen.Duk da haka, binciken ya nuna cewa magungunan paclitaxel da kanta na iya haifar da halayen haɓaka, amma a ƙananan kuɗi idan aka kwatanta da allurar paclitaxel.A halin yanzu, paclitaxel liposomes har yanzu suna buƙatar maganin rashin lafiyar kafin amfani.
4. Albumin-bound paclitaxel: Wani sabon paclitaxel albumin lyophilized wakili ta yin amfani da albumin ɗan adam a matsayin mai ɗaukar magunguna da stabilizer, wanda ba ya ƙunshe da co-solvent polyoxyethylene-substituted castor oil kuma yana da ƙarancin abun ciki na paclitaxel tare da paclitaxel liposomes, kuma baya da. bukatar pretreatment kafin magani.
Lura: Ana ɗaukar yuwuwar inganci da aikace-aikacen da aka rufe a cikin wannan gabatarwar daga wallafe-wallafen da aka buga.
Yunnan Hande Biotechnology Co., Ltd ya ƙware wajen samar da kayayyakipaclitaxel APIfiye da shekaru 20, kuma yana ɗaya daga cikin masana'antun masu zaman kansu na duniya na paclitaxel API, maganin ciwon daji da aka samo daga shuka, wanda FDA ta Amurka, Turai EDQM, TGA ta Ostiraliya, CFDA na kasar Sin, Indiya, Japan da sauran hukumomin kula da harkokin kasa suka amince da su. .Hande na iya samar da ba kawai high quality-paclitaxel albarkatun kasa, amma kuma ayyukan haɓaka fasaha masu alaƙa da ƙirar paclitaxel.Don ƙarin bayani, da fatan za a tuntuɓe mu a 18187887160.
Lokacin aikawa: Dec-08-2022