Ɗauki ku ta hanyar haɗin haɗin paclitaxel

Paclitaxel shi ne na halitta na biyu metabolite keɓe da kuma tsarkake daga haushi na ja fir.A asibiti an tabbatar da cewa yana da sakamako mai kyau na rigakafin cutar kansa, musamman akan ciwon daji na ovarian, mahaifa da nono, waɗanda ke da yawan kamuwa da cutar kansa.A halin yanzu,na halitta paclitaxelda Semi-synthetic paclitaxel suna samuwa a kasuwa.Labari mai zuwa zai ɗauke ku ta hanyar haɗin paclitaxel.

Paclitaxelana cikowa daga bawon da ganyen wannan tsiron, kuma aikin hakowa yana da sarkakiya, ba a iya narkewa a cikin ruwa da barasa, kuma abin da ke cikinsa ya ragu sosai, kawai 100g, watau teels na paclitaxel guda biyu, ana iya fitar da shi daga busasshen bawon ton 30. .Ko da yake an gama haɗin haɗin sinadarai gabaɗaya a cikin dakin gwaje-gwaje, ya ƙunshi matakai da yawa, yanayi mai tsauri, tsada da ƙarancin amfanin ƙasa.Sabili da haka, har yanzu ba zai yiwu a samar da shi ta hanyar masana'antu ta hanyar haɗin sinadarai ba, wanda ke sa shi tsada sosai.

Tun na halittapaclitaxelAna fitar da yew daga Pacific yew, wanda shine tushen da ba kasafai ba, kuma yanayin girma na yew na halitta yana da tsayi, kusan kilogiram 13.6 na haushi don cire gram 1 na paclitaxel, kuma itacen yew 3-12 sama da shekaru 100 ana buƙatar magani ɗaya. masu fama da ciwon daji, samar da dogon lokaci da farashi mai yawa sun haifar da saurin haɓaka fasahar roba na paclitaxel.

A halin yanzu, babban hanyar haɗin paclitaxel shine hanyar bioengineering, wanda kuma aka sani da paclitaxel semisynthesis.Ana amfani da hanyar bioengineering don samar da paclitaxel a kan babban sikelin ta hanyar kiwo da kuma tantance nau'ikan da za su iya samar da adadi mai yawa na paclitaxel, sa'an nan kuma ta hanyar ci gaba da haɓaka su, canzawa da inganta tsarin kwayoyin halitta, ana iya samar da paclitaxel a cikin al'adun gargajiya "ba tare da al'ada ba. iyakance”, kuma ba a ƙara iyakance shi da ƙarancin albarkatun ƙasa.Sakamakon bincike na baya-bayan nan ya nuna cewa an inganta haɓakar haɓakar haɓakar haɓakar haɓakar haɓakar nau'in nau'in nau'in nau'in gram 448.52 na paclitaxel kowace lita na al'ada.

Haɗin sinadarai, kodayake an kammala, bai dace da masana'antu ba saboda ƙaƙƙarfan yanayin da ake buƙata, ƙarancin amfanin ƙasa, da tsada mai tsada.Hanyar Semi-synthetic na paclitaxel yanzu ya fi girma kuma ana ɗaukarsa a matsayin hanya mai inganci don faɗaɗa tushen paclitaxel ban da noman wucin gadi.Hanyar Semi-synthetic na iya yin amfani da albarkatun shuka sosai.

Lura: Ana gabatar da yuwuwar inganci da aikace-aikacen da aka rufe a cikin wannan takarda daga wallafe-wallafen da aka buga.

Karin karatu:Yunnan Hande Biotechnology Co., Ltd yana mai da hankali kan samar da paclitaxel tsawon shekaru 28.Ita ce masana'anta ta farko mai zaman kanta a duniya na paclitaxel na maganin ciwon daji da aka samo daga shuka wanda FDA ta Amurka, Turai EDQM, TGA ta Australiya, China CFDA, Indiya, Japan da sauran hukumomin kula da ƙasa suka amince.kamfani.Idan kana so ka sayaPaclitaxel API, don Allah a tuntube mu akan layi.