Paclitaxel wani samfuri ne na halitta wanda aka samo asali daga haushi na itacen yew na Pacific (Taxus pacifica) biosynthesis na paclitaxel ya ƙunshi hadaddun hanyoyin biosynthetic, gami da enzymes da yawa da tsaka-tsaki. Kalubale a ainihin samar da masana'antu.Ga cikakken bayyani na biosynthesis na paclitaxel:
1.Farawa abu: Biosynthesis na paclitaxel yana farawa da kayan farawa na halitta, yawanci daga ganye ko haushi na itacen yew.Waɗannan kayan farawa sun ƙunshi mahaɗan iyaye waɗanda za a iya amfani da su don haɗa abubuwan da suka gabata na paclitaxel.
2.Multi-enzyme catalysis: Biosynthesis napaclitaxelYana buƙatar enzymes da yawa don kunna halayen.Wadannan enzymes suna canza abin farawa zuwa tsaka-tsaki waɗanda sannu a hankali suna haɗa ƙwayoyin precursor na paclitaxel.
3.Synthesis na tsaka-tsaki: Matsakaicin mataki ne mai mahimmanci a cikin haɗin haɗin paclitaxel. Sun ƙunshi mahaɗan polycyclic da sassan sassan sassan da aka haɗa a hankali ta hanyar jerin halayen enzyme-catalyzed.
4.Final kira na paclitaxel: Abubuwan da aka riga aka tsara don kira na paclitaxel an haɗa su a hankali a cikin kwayoyin paclitaxel a cikin matakan amsawa da yawa. Waɗannan halayen sun haɗa da haɗin polycyclic, acylation, deketone, da sauran matakai masu mahimmanci.
5.Extraction da tsarkakewa: Bayan kira na paclitaxel, ana buƙatar cirewa da matakin tsarkakewa don raba paclitaxel mai tsabta daga cakuda dauki.
Ko da yake na halitta biosynthetic hanyoyinpaclitaxelAn yi nazari, ainihin samar da paclitaxel ya kasance mai wuyar gaske saboda yana buƙatar hadaddun haɗakarwa tare da matakai masu yawa da yawa na albarkatun kasa.Saboda waɗannan ƙalubalen, masana kimiyya sun kuma bincika hanyoyin haɗin gwiwar don haɗa paclitaxel don ƙara yawan amfanin ƙasa da samuwa.Synthetic kira na paclitaxel yawanci ya ƙunshi hanya mafi sauƙaƙan kira don rage rikitarwa.
Lura: Abubuwan fa'idodi da aikace-aikacen da aka gabatar a cikin wannan labarin an samo su ne daga wallafe-wallafen da aka buga.
Yunnan Hande Biotechnology Co., Ltd ya mai da hankali kan samar da paclitaxel na tsawon shekaru 26, kuma shi ne mai zaman kansa ƙera na shuka-extracted anti-cancer magani paclitaxel API amince da Amurka FDA, Turai EDQM, Ostiraliya TGA, China CFDA. ,Indiya,Japan da sauran hukumomin kula da harkokin kasa.Yunnan Hande paclitaxel,tabo,sayar da masana'anta kai tsaye,barka da zuwa tambaya,18187887160(WhatsApp iri daya)
Lokacin aikawa: Oktoba-12-2023