Tsarin samarwa don Paclitaxel, maganin da ake amfani da shi sosai a cikin maganin ciwon daji, tsari ne mai rikitarwa da haɓaka wanda ke rufe matakai da yawa, daga cirewa daga tushen halitta zuwa ƙirar magunguna na ƙarshe.Wannan takarda za ta gabatar da tsarin samarwa napaclitaxel, daga hakar zuwa shiri.
Mataki 1: Cire
PaclitaxelAn samo asali ne daga bawon itacen yew na Pacific, Taxus pacifica.Tsarin yana farawa tare da tarin haushi kuma yawanci yana buƙatar kulawa da hankali don guje wa lalacewa ga bishiyar.An karye kayan haushin da aka tattara sannan a saka shi cikin wani kaushi mai dacewa, kamar ether ko xylene.Ana narkar da Paclitaxel daga haushi zuwa wani ƙarfi a cikin wannan matakin don samar da tsantsa.
Mataki na 2: Rabuwa
Abubuwan da ake cirewa sukan ƙunshi nau'ikan mahadi daban-daban, don haka paclitaxel yana buƙatar rabuwa da wasu mahadi.Wannan matakin yawanci yana amfani da chromatographic chromatography ko wasu dabarun rabuwa don raba paclitaxel daga wasu abubuwa dangane da kaddarorin fili.
Mataki na 3: Tsarkakewa
The raba paclitaxel yana buƙatar ƙara tsarkakewa don cire duk wani ƙazanta da ya rage kuma a sami samfur mai tsafta.Wannan yawanci ya ƙunshi matakai kamar crystallization, tacewa, da recrystallization don tabbatar da cewa paclitaxel na ƙarshe yana da tsafta.
Mataki na 4: Haɗa (na zaɓi)
Kodayake an fitar da asalin paclitaxel daga tushen halitta, kamfanonin harhada magunguna da yawa sun haɓaka hanyoyin haɗa shi.Waɗannan hanyoyin suna amfani da hanyoyin sinadarai na roba don haɓaka yawan amfanin ƙasa da sarrafawa da rage dogaro ga albarkatun ƙasa.
Mataki na 5: Shirya miyagun ƙwayoyi
Mataki na ƙarshe a cikin tsarin samarwa shine shirye-shiryen paclitaxel mai tsabta a cikin shiri don amfani da likita.Wannan na iya haɗawa da narkar da paclitaxel a cikin abin da ya dace, kamar barasa ko ether, don shirya shi cikin shiri na magunguna.An shirya mafi yawan nau'i na yau da kullum azaman maganin allura don tabbatar da daidaitaccen allurai.
A hade tare, tsarin samar dapaclitaxelwani tsari ne mai rikitarwa da matakai da yawa da aka tsara don tabbatar da tsabta mai tsabta da sarrafawa na miyagun ƙwayoyi na ƙarshe.Nasarar wannan tsari yana da mahimmanci ga isar da ingantaccen maganin cutar kansa don haka koyaushe ana ingantawa da haɓakawa don biyan bukatun likita.
Lura: Abubuwan fa'idodi da aikace-aikacen da aka gabatar a cikin wannan labarin an samo su ne daga wallafe-wallafen da aka buga.
Yunnan Hande Biotechnology Co., Ltd. ya mai da hankali kan samar da paclitaxel na tsawon shekaru 26, kuma shi ne mai zaman kansa mai sana'a na maganin ciwon daji na paclitaxel API wanda ya amince da FDA ta Amurka, Turai EDQM, Australia TGA, China CFDA , Indiya, Japan da sauran hukumomin gudanarwa na kasa.Yunnan Hande paclitaxel, tabo wadata, masana'anta kai tsaye tallace-tallace, maraba don tambaya, 18187887160 (WhatsApp lamba iri ɗaya)
Lokacin aikawa: Oktoba-13-2023