Yew taxus chinensis ana fitar da shi daga tsire-tsire masu ƙarancin yanayi, shimfiɗa, kara, fata, tushen ya ƙunshi manyan sinadarai sune: yew alkali diterpenoid mahadi, yew ning A da yew, yew ning H, yew ning K,l, yew alkali, Jinsong yellow ketone, gangara wanda ya bar A, wannan barin ketone ketone, jinsong double yellow ketone, naphtha, yew, polysaccharide, tannins, tanned ja, da dai sauransu, na iya ƙunshi sauran polyphenols, amino acid, itacen guduro, inorganic element. anti-leukemia da ciwon daji effects.
Paclitaxel, wanda za mu yi magana game da shi, shine mafi kyawun maganin ciwon daji na halitta wanda aka samo ya zuwa yanzu.An yi amfani dashi sosai a maganin ciwon nono, ciwon daji na ovaries, kansa da wuyansa, ciwon huhu da yawa. sauran ciwon daji na asibiti.
Natural Paclitaxel vs Semi-synthetic Paclitaxel
Najasa:
Na halitta paclitaxelAna fitar da shi daga tushen, tushe da ganyen Taxus chinensis.Bayan shafi chromatography da recrystallization, dukan tsari shine hakar jiki da tsarkakewa ba tare da halayen sinadaran ba. An kawo shi ta hanyar haɗakar sinadarai.Saboda haka, ƙayyadaddun ƙazanta na paclitaxel na halitta an fi yin nazari sosai kuma ana iya sarrafa su a halin yanzu.
Semi-synthetic paclitaxelyana da sinadari da yawa fiye da na halitta a cikin tsarinsa, haka nan kuma mabubbugar najasa su ma sun fi na halitta, ciki har da wasu da ake hakowa daga tsirrai, da kuma wasu najasa da ake samu ta hanyar hada sinadaran. A cikin wannan tsari, yawa da nau'in ƙazanta suna canzawa akai-akai.Saboda haka, Semi-synthetic paclitaxel yana da ƙarancin sarrafawa a cikin ƙazanta, kuma sabbin ƙazantattun abubuwa suna buƙatar yin nazari akai-akai a cikin tsarin samarwa. daban-daban, kuma ana buƙatar takamaiman bincike.
Yunnan Hande Bio-Tech ya shafe shekaru 30 yana aikin hakowa da haɓaka haraji, kuma ainihin samfuransa.na halitta paclitaxel,10-DAB Semi-synthetic paclitaxel,10-deacetylbaccatin III,docetaxel,cabazitaxel,da sauransu.Don ƙarin bayani game da paclitaxel APIs, da fatan za a tuntube mu!!!(Whatsapp/Wechat:+86 18187887160)
Lokacin aikawa: Janairu-19-2023