Ta yaya paclitaxel ke yaƙar kansa?

Paclitaxel wani diterpenoid ne da aka samo daga Taxus Genus Taxus, kuma masana kimiyya sun gano cewa yana da aikin antitumor mai karfi a cikin gwaje-gwajen gwaji.A halin yanzu,paclitaxelana amfani da shi sosai wajen magance cutar kansar nono, kansar kwai, kansar huhu mara ƙanƙanta, kansar pancreatic, kansar hanji, ciwon ciki, ciwon kai da wuyansa, sarcoma mai laushi da sauran muggan ciwace-ciwace, kuma yana ɗaya daga cikin mafi yawan lokuta. amfani da magungunan chemotherapy a aikin asibiti.Don haka ta yaya ainihin paclitaxel ke yaƙar ciwon daji?Bari mu duba a kasa.

Ta yaya paclitaxel ke yaƙar kansa?Sanannen abu ne cewa yayin rarraba tantanin halitta ta al'ada, tantanin halitta ya kasu kashi biyu.Bayan an kwafi chromosome ɗin, filament ɗin spindle ɗin yana jan shi daga ainihin matsayinsa zuwa ɓangarorin biyu, kuma sandal ɗin yana buƙatar depolymerization na microtubules kamar yadda cytoskeleton ya zama, chromosomes na iya kammala mitosis ne kawai ta hanyar motsawa zuwa sanduna a ƙarƙashin gogayya na sandar kuma. filament na spindle, don haka microtubules suna da matukar muhimmanci a rarraba tantanin halitta.

A cikin 1979, masanin harhada magunguna Horwitz ya gano hakanpaclitaxelzai iya ɗaure zuwa tubulin kuma ya inganta polymerization na tubulin don samar da microtubules, ta haka ne ya hana tsarin ilimin lissafi na al'ada na microtubules, yana sa ya kasa samar da spindles da filaments na spindle, yin sel Rashin iyawar rarraba kullum yana hana saurin haifuwa na kwayoyin cutar kansa kuma yana haifar da apoptosis. na kwayoyin cutar daji.Sabili da haka, a cikin magungunan anticancer, ana ɗaukar paclitaxel azaman mai hana microtubule a cikin mitosis.

Lura: Yiwuwar inganci da aikace-aikacen da aka bayyana a cikin wannan labarin an samo su daga wallafe-wallafen da aka buga.

Karin karatu:Yunnan Hande Biotechnology Co., Ltd yana mai da hankali kan samar da paclitaxel tsawon shekaru 28.Ita ce masana'anta ta farko mai zaman kanta a duniya na paclitaxel na maganin ciwon daji da aka samo daga shuka wanda FDA ta Amurka, Turai EDQM, TGA ta Australiya, China CFDA, Indiya, Japan da sauran hukumomin kula da ƙasa suka amince.kamfani.Idan kana so ka sayaPaclitaxel API,don Allah a tuntube mu akan layi.