Halayen paclitaxel mai ɗaure albumin, Magungunan Anticancer

Paclitaxel samfuri ne na halitta wanda aka samo daga Taxus, wanda ke aiki akan tubulin don hana mitosis na ƙwayoyin ƙari. inganci na asibiti mai kyau a cikin maganin ciwon nono, kansar ovarian, kansar huhu mara ƙarami, kansar gastroesophageal da sauran ciwace-ciwace.

Saboda gargajiya paclitaxel ne sosai lipophilic, da kuma aiki sashi yana da wuya a narke a cikin ruwa, anhydrous ethanol, polyoxyethylene Castor man, da dai sauransu ana amfani da su a cikin shiri tsari don taimaka ta narke.Waɗannan kwayoyin kaushi ne mai sauki sa rashin lafiyan halayen a marasa lafiya. kuma a cikin lokuta masu tsanani, anaphylactic shock na iya faruwa, yana haifar da haɗari ga rayuwa. Abubuwan da ke haifar da rashin lafiyar jiki sun kai 20% -40% . Don ingantaccen rigakafi, dole ne a yi maganin rigakafi tare da corticosteroids da antihistamines kafin gudanarwa. Paclitaxel yana buƙatar diluted a ciki. da yawa kafin allura na cikin jini, kuma lokacin jiko yana buƙatar kiyaye akalla sa'o'i 3.

Domin shawo kan wannan lahani, albumin-bound paclitaxel ya zo cikin kasancewa. Albumin-bound paclitaxel ya haɗu da paclitaxel na hydrophobic tare da albumin don samar da nanoparticles tare da girman barbashi na kusan 130 nm ta hanyar amfani da nanotechnology na musamman. albumin don sa paclitaxel ya fi rarrabawa a cikin ƙwayoyin tumor kuma ya kai matsayi mafi girma a cikin ƙwayoyin tumor; Yana guje wa amfani da ethanol anhydrous, polyoxyethylene castor man da sauran abubuwan narkewa, yana rage yawan bayyanar rashin lafiyar jiki, kuma baya buƙatar maganin rashin lafiyan kafin amfani. , kuma baya buƙatar yin amfani da na'urar jiko na musamman. Za'a iya kammala jiko a cikin rabin sa'a. Yana da gaske ya sami babban sakamako mai warkarwa da ƙananan guba.

Lura: Yiwuwar inganci da aikace-aikacen da aka gabatar a cikin wannan labarin duk sun fito ne daga wallafe-wallafen da aka buga.

Yunnan Hande Biotechnology Co., Ltd ya ƙware a cikin samar dapaclitaxel APIfiye da shekaru 20, kuma yana ɗaya daga cikin masana'antun masu zaman kansu na duniya na paclitaxel API, maganin ciwon daji da aka samo asali, wanda Amurka FDA ta amince da shi, EDQM na Turai, TGA Ostiraliya, CFDA na kasar Sin, Indiya, Japan da sauran hukumomin kula da ƙasa. .Hande zai iya samar da ba kawai high quality-paclitaxel albarkatun kasa,amma kuma ayyukan haɓaka fasaha masu alaƙa da ƙirar paclitaxel.Don ƙarin bayani, da fatan za a ji daɗin tuntuɓar mu a 18187887160.