Paclitaxel yana daya daga cikin magungunan chemotherapy na ƙarni uku na gargajiya, amma rashin ruwa na ruwa ba shi da kyau kuma yana buƙatar narkar da shi tare da kayan kaushi. kawai yana guje wa hypersensitivity / guba da ke haifar da maganin kwayoyin halitta, amma kuma baya buƙatar pretreatment na hormone; Yana kuma iya sa albumin ya dauki paclitaxel daga cikin jini da sauri, wucewa ta sel endothelial ta hanyar endocytosis mai karɓa na tsakiya, kuma ya wadata mafi a cikin ƙwayoyin tumo. ta hanyar babban haɓakawa da sakamako mai riƙewa (EPR sakamako) na ciwace-ciwace, wanda ke ci gaba da nuna fa'idodin pharmacokinetic.
A zamanin immunotherapy, ingancin magani guda bai isa ba, kuma ƙimar gafarar haƙiƙa (ORR) na magani ɗaya bai wuce 20% ba; Yadda za a faɗaɗa masu cin gajiyar immunotherapy, haɗin gwiwa na iya zama mafita mai inganci, daga ciki yanayin haɗin chemotherapy shine wuri mai zafi na bincike na yanzu.
Daga wannan hangen nesa, albumin-bound paclitaxel yana da nasa fa'idodi, ORR ya fi girma, yana iya kashe ƙwayoyin tumor yadda ya kamata, kuma yana haɓaka bayyanar antigen tumor; Ba a buƙatar pretreatment na hormone don guje wa rigakafi; Babban haɓakar ƙwayar ƙwayar cuta yana rage lalacewa kyallen takarda na al'ada.
Lura: Yiwuwar inganci da aikace-aikacen da aka gabatar a cikin wannan labarin duk sun fito ne daga wallafe-wallafen da aka buga.
Yunnan Hande Biotechnology Co., Ltd ya ƙware a cikin samar dapaclitaxel APIfiye da shekaru 20, kuma yana ɗaya daga cikin masana'antun masu zaman kansu na duniya na paclitaxel API, maganin ciwon daji da aka samo asali, wanda Amurka FDA ta amince da shi, EDQM na Turai, TGA Ostiraliya, CFDA na kasar Sin, Indiya, Japan da sauran hukumomin kula da ƙasa. .Hande zai iya samar da ba kawai high quality-paclitaxel albarkatun kasa,amma kuma ayyukan haɓaka fasaha masu alaƙa da ƙirar paclitaxel.Don ƙarin bayani, da fatan za a ji daɗin tuntuɓar mu a 18187887160.
Lokacin aikawa: Dec-29-2022