Paclitaxel wani sinadari ne na halitta da aka fitar daga shuka yew, wanda ke da gagarumin aikin rigakafin cutar kansa.Tun da aka fara keɓe paclitaxel daga haushin yew na Pacific a 1971, bincikensa a fannin maganin ciwon daji ya kasance mai ban sha'awa sosai. bincika cikin zurfin hanyoyin warkewa napaclitaxelakan nau'ikan ciwon daji daban-daban.
Tsarin da kaddarorin paclitaxel
Paclitaxel wani hadadden tetracyclic diterpenoid fili ne tare da keɓaɓɓen tsari mai girma uku, wanda ke ba da tushe don ayyukan rigakafin cutar kansa. Tsarin kwayoyin halittarsa shine C47H51NO14, nauyin ƙwayoyin cuta shine 807.9, kuma yana da launin rawaya crystalline foda a zafin jiki.
Tsarin rigakafin ciwon daji napaclitaxel
Tsarin anti-ciwon daji na paclitaxel yana da alaka da hanawa na tubulin depolymerization da tasirinsa akan rarrabawar kwayar halitta da haɓakawa. Bugu da ƙari, paclitaxel kuma zai iya haifar da apoptosis cell kuma ya hana ciwon angiogenesis.
Tasirin warkewa na paclitaxel akan nau'ikan ciwon daji daban-daban
1.Cusar nono: An san tasirin warkewar paclitaxel akan kansar nono.A cikin binciken da aka yi akan masu cutar kansar nono 45, paclitaxel tare da chemotherapy ya haifar da raguwar ƙari a cikin 41% na marasa lafiya da ma'anar rayuwa fiye da watanni 20.
2.Non-small cell huhu cancer: Ga wadanda ba karamin cell ciwon daji ba, paclitaxel hade da platinum na tushen chemotherapy magunguna na iya inganta rayuwar marasa lafiya sosai.Bincike na 36 marasa lafiya tare da ciwon huhu marasa ƙananan ƙwayoyin cuta ya nuna cewa paclitaxel hade tare da chemotherapy ya haifar da rayuwa ta tsaka-tsaki na watanni 12.
3. Ciwon daji na Ovarian: A cikin jiyya na masu ciwon daji na ovarian 70, paclitaxel hade tare da maganin chemotherapy na platinum sun rage ciwace-ciwacen daji a cikin 76% na marasa lafiya, kuma tsawon shekaru biyu na rayuwa ya kai 38%.
4. Ciwon daji na Esophageal: A cikin kula da marasa lafiya 40 masu ciwon daji na esophageal, paclitaxel hade tare da radiotherapy rage ciwace-ciwacen daji a cikin 85% na marasa lafiya, kuma adadin rayuwa na shekara guda ya kai 70%.
5.Gastric cancer: A cikin maganin ciwon daji na ciki, paclitaxel tare da fluorouracil na iya inganta rayuwar marasa lafiya sosai.A cikin nazarin marasa lafiya 50 da ciwon ciki,paclitaxelhaɗe da chemotherapy ya haifar da rayuwa ta tsaka-tsaki na watanni 15.
6.Colorectal cancer: A cikin jiyya na 30 marasa lafiya na colorectal, paclitaxel hade tare da oxaliplatin rage ciwace-ciwacen daji a cikin 80% na marasa lafiya, da kuma shekaru biyu rayuwa adadin ya kai 40%.
7.Cancer hanta: Ko da yake tasirin paclitaxel monotherapy akan ciwon hanta yana da iyakancewa, haɗuwa da wasu magungunan chemotherapy irin su cisplatin da 5-fluorouracil na iya inganta rayuwar marasa lafiya sosai. Nazarin 40 marasa lafiya da ciwon hanta ya nuna cewa paclitaxel hade. tare da chemotherapy ya haifar da rayuwa ta tsaka-tsaki na watanni 9.
8.Kidney Cancer: A cikin maganin ciwon koda, paclitaxel tare da magungunan immunomodulatory irin su interferon-alpha na iya inganta rayuwar marasa lafiya sosai.Bincike na marasa lafiya 50 da ke fama da ciwon koda ya nuna cewa paclitaxel tare da immunotherapy ya haifar da rayuwa ta tsakiya. watanni 24.
9.Cutar cutar sankarar bargo: A cikin maganin cutar sankarar myeloid mai tsanani, paclitaxel tare da magungunan chemotherapy irin su cytarabine na iya sa marasa lafiya su sami mafi girman adadin gafara. Binciken marasa lafiya 30 da ke fama da cutar sankarar bargo mai tsanani ya nuna cewa paclitaxel tare da chemotherapy ya haifar da cikakkiyar amsa. a cikin 80% na marasa lafiya.
10, Lymphoma: A cikin maganin lymphoma ba Hodgkin, paclitaxel tare da magungunan chemotherapy irin su cyclophosphamide na iya ba marasa lafiya damar samun cikakkiyar amsawa. a cikin cikakkiyar amsa a cikin 85% na marasa lafiya.
Kammalawa
A taƙaice, paclitaxel ya nuna wani tasiri a cikin maganin ciwon daji daban-daban. Duk da haka, yana da mahimmanci a lura cewa tasirin magani ya bambanta ga kowane nau'in ciwon daji kuma ana buƙatar sau da yawa a hade tare da wasu magunguna. Bugu da ƙari, saboda ciwon daji. rikitarwa da bambance-bambancen mutum na ciwon daji, tsare-tsaren magani ya kamata a keɓance ga kowane mai haƙuri.Nazari na gaba ya kamata ya kara bincika yuwuwar paclitaxel a cikin maganin ciwon daji da haɓaka amfani da shi.
Lura: Abubuwan fa'idodi da aikace-aikacen da aka gabatar a cikin wannan labarin an samo su ne daga wallafe-wallafen da aka buga.
Lokacin aikawa: Nuwamba-17-2023