Magungunan Na'ura
Paclitaxel, a matsayin maganin ciwon daji, ana amfani dashi sosai a cikin allurai da na'urori daban-daban.
An fi yin shi ta hanyar hakar halitta da kira.
A matsayin tushen shuka na paclitaxel ta halitta, Taxus Chinensis, yana da ƙarancin ƙarancin girma kuma yana da tsayi mai tsayi, ana samun jerin hanyoyin kira sannu a hankali daga paclitaxel ta hanyar bincike da gwaje-gwaje a duniya, gami da jimlar kira, Semi-kir, da endophytic kira.
Saboda da dogon sinadaran kira hanya, da yawa kira matakai, da wuya a sarrafa dauki yanayi, da cikakken hada paclitaxel bukatar yin amfani da mafi tsada sinadaran reagents, da yawan amfanin ƙasa ne kuma low, wanda bai dace da taro samar da masana'antu samar a cikin. na gaba ɗaya.
Saboda haka, in mun gwada da babban adadin paclitaxel a kasuwa ana yin shi gabaɗaya ta hanyar haɓakar haɓakar haraji da hanyoyin haɗin gwiwa.
Natural Paclitaxel vs Semi-synthetic Paclitaxel
Sashe na 1:Tsarin samarwa
-Danye kayan: Yew da aka dasa ta wucin gadi
-Tsarin cirewa: albarkatun ƙasa + chromatography na ginshiƙi + recrystallization = samfurin gama
-Tsarin cirewa: amsawar jiki, babu tsarin haɗin sinadarai
-Danye kayan: Yew da aka dasa ta wucin gadi
-Tsarin hakar: albarkatun kasa + sinadaran reagent dauki + maida hankali crystallization + daban-daban sinadaran halayen + recrystallization = gama samfurin
-Tsarin cirewa: halayen sinadaran
Dangane da fasaha, paclitaxel na halitta yana da matakan cirewa mafi sauƙi idan aka kwatanta da paclitaxel na wucin gadi da kuma ƙarin fa'ida akan paclitaxel na wucin gadi dangane da kwanciyar hankali da aminci, yayin da paclitaxel na wucin gadi yana rage farashin ci gaban samfur dangane da farashi da albarkatun ƙasa. ,da kuma inganta wasu matsalolin da karancin albarkatun kasa ke haifarwa a kasuwa.
Idan aka kwatanta da hanyoyi guda biyu na samar da paclitaxel, paclitaxel na halitta yana da mafi kyawun kwanciyar hankali da aminci a cikin na'urorin kiwon lafiya, wanda shine dalili daya da ya sa yawancin kamfanonin na'urorin kiwon lafiya a kasuwa suna amfani da paclitaxel na halitta a matsayin albarkatun kasa.
Yunnan Hande Biotechnology Co., Ltd ya tsunduma cikin hakar da kuma bunkasa haraji na tsawon shekaru 30, kuma ainihin kayayyakinsa sune paclitaxel na halitta, 10-DAB Semi-synthetic paclitaxel, 10-deacetylbaccatin III, docetaxel, cabazitaxel, da dai sauransu. ƙarin bayani game da paclitaxel APIs, da fatan za a tuntuɓe mu!!!(Whatsapp/Wechat:+86 18187887160)
Lokacin aikawa: Janairu-17-2023