Paclitaxel magani ne mai mahimmanci wanda ake amfani dashi sosai a cikin maganin cutar kansa, amma tushen sa na halitta yana da iyaka.Don saduwa da buƙatun paclitaxel a cikin kasuwannin magunguna, masana kimiyya sun gudanar da bincike mai zurfi, tare da hanyoyin haɗin gwiwar haɗin gwiwa sun zama mahimmancin yanayin samarwa.Wannan labarin zai gabatar da tsari na Semi-synthesizing paclitaxel daga 10-deacetylbaccatin III (10-DAB) kuma ya jaddada mahimmancinsa a fagen hada magunguna.
Paclitaxel, wanda asalinsa keɓe daga haushin bishiyar yew na Pacific, ya shahara saboda fitattun abubuwan da ke hana cutar daji.Koyaya, yew na Pacific ƙaƙƙarfan albarkatun ƙasa ne, bai isa ya cika buƙatun likitancin zamani na paclitaxel ba.Haɓaka hanyoyin da aka yi amfani da su na wucin gadi ya sanya babban sikelin samar da paclitaxel mai yiwuwa, tare da 10-deacetylbaccatin III kasancewa matsakaici mai mahimmanci.
Shiri na 10-DAB a cikin Semi-Synthetic Paclitaxel:
10-DAB shine matsakaici mai mahimmanci a cikin hanyar Semi-synthetic zuwa paclitaxel kuma yana buƙatar matakai da yawa don shirye-shiryen sa.Yawanci, haɗin 10-DAB yana farawa da ainihin ma'anar paclitaxel, taxuyunnanine C, wanda aka samo daga baccatin III.Baccatin III an fara deacetylated don samar da 10-deacetylbaccatin III.Daga baya, 10-deacetylbaccatin III yana fuskantar halayen da yawa, gami da hydrogenation, canji, epoxidation, hydrolysis, da ƙari, a ƙarshe yana canzawa zuwa 10-DAB.
Aikace-aikace na 10-DAB a cikin Semi-Synthetic Paclitaxel:
Ƙaddamar da 10-DAB ya buɗe wani sabon hanya don ƙaddamar da ƙananan kira na paclitaxel, yana ba da dorewa a cikin samar da kwayoyi.Paclitaxel magani ne mai fa'ida mai faɗi da ake amfani da shi wajen magance nau'ikan ciwon daji daban-daban, gami da ovarian, nono, da kansar huhu.Hanyar Semi-synthetic yana rage farashin samar da magunguna, yana mai da wannan zaɓin magani mai mahimmanci don samun dama ga marasa lafiya.
Ƙarshe:
Hanyar Semi-synthesizing paclitaxel daga 10-DAB ta sami babban nasara a fagen hada magunguna.Ba wai kawai yana magance batun ƙayyadaddun tushen asalin halitta don paclitaxel ba amma yana haɓaka haɓakar samarwa da dorewa.Wannan fasaha tana wakiltar wani ci gaba a cikin samar da magungunan cutar kansa kuma yana da alƙawarin ci gaba da ci gaba a fannin likitanci don yaƙar cututtuka masu tsanani kamar ciwon daji.A nan gaba, masu bincike za su ci gaba da tsaftace hanyoyin haɗin gwiwar don inganta inganci da rage farashi, a ƙarshe suna amfana da fa'idodin marasa lafiya.
Lura: Yiwuwar fa'idodi da aikace-aikacen da aka ambata a cikin wannan labarin sun dogara ne akan wallafe-wallafen jama'a.
Kara karantawa: Yunnan Hande Biotech Co., Ltd., tare da shekaru 26 na mai da hankali kan samar da paclitaxel, kamfani ne mai zaman kansa mai zaman kansa wanda aka amince da shi a duniya na masana'antar maganin cutar daji da aka fitar da paclitaxel mai aiki da sinadarai, wanda hukumomin gudanarwa irin su US FDA, Turai EDQM suka amince da su. , Australia TGA, China CFDA, India, Japan, da sauransu.Yunnan Hande Paclitaxel, ana samunsa a hannun jari, masana'anta ke siyar da su kai tsaye.Da fatan za a iya jin daɗin kiran tambaya ta +86 18187887160 (WhatsApp).
Lokacin aikawa: Oktoba-24-2023